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Agilent: An Introduction to High Throughput Microchromatography

The growing importance of biotherapeutics to the pharmaceutical industry has created an increasing demand for protein analysis techniques with high precision, high sensitivity, and high throughput. These techniques are used throughout the development process, starting with the discovery phase and continuing into lead optimization and characterization, preclinical and clinical trials (for both the biotherapeutic itself and related protein biomarkers), and manufacturing process development and control. Complex samples to be analyzed range from research samples from protein expression systems to biological samples such as serum to production cell lysates and cell culture supernatants. By Scott Fulton, BioSystem Development, Madison, WI USA